Tier 2 — strong

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men

Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barrès R, Larsen S, Prats C, Jessen N, Treebak JT
The Journal of physiology 2020 598; 4; 731-754

Bibliography

PubMed
PMID 31710095
DOI
10.1113/jp278752
Funding
Funding details are not specified in the accessible publication information.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignMuscle-biopsy analysis of a randomized placebo-controlled trial
ModelHuman participants
Sample40 men; muscle-imaging subset of 16
InterventionNR 1000 mg twice daily versus placebo
Duration12 weeks
EndpointsMuscle mitochondrial respiration; content; morphology

What the study showed, in plain terms

Muscle mitochondrial respiration, content and morphology were unchanged after NR, despite a decrease in NAMPT protein abundance.

Key findings

Muscle mitochondrial respiration, content and morphology were unchanged after NR, despite a decrease in NAMPT protein abundance.

What this study can and cannot tell us

Companion muscle analysis of the obesity trial reported in PMID 29992272; not a separate clinical cohort.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology