Tier 2 — strong

Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise

Stocks B, Ashcroft SP, Joanisse S, Dansereau LC, Koay YC, Elhassan YS, Lavery GG, Quek LE, O'Sullivan JF, Philp AM, Wallis GA, Philp A
The Journal of physiology 2021 599; 5; 1513-1531

Bibliography

PubMed
PMID 33492681
DOI
10.1113/jp280825
Funding
Indexed grant support includes Biotechnology and Biological Sciences Research Council. The complete funding declaration is not specified in the accessible abstract.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignRandomized placebo-controlled human trial
ModelHuman participants
Sample8 young men
InterventionNR 1000 mg/day versus cellulose placebo
Duration7 days followed by an endurance-exercise bout
EndpointsSubstrate use; muscle respiration; exercise signaling

What the study showed, in plain terms

NR altered several muscle NAD-related metabolites but did not change substrate use, muscle respiration or the measured exercise-signaling pathways.

Key findings

NR altered several muscle NAD-related metabolites but did not change substrate use, muscle respiration or the measured exercise-signaling pathways.

What this study can and cannot tell us

Very small, short study. It does not establish effects of long-term training or outcomes in older or deficient populations.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology