Tier 2 — strong

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG
Cell reports 2019 28; 7; 1717-1728.e6

Bibliography

PubMed
PMID 31412242
PubMed Central
PMC6702140
DOI
10.1016/j.celrep.2019.07.043
Funding
Support included the UK Medical Research Council, Wellcome, musculoskeletal-aging research programs, NIH and charitable funding.
Competing interests
Disclosures include ChromaDex equity, licensed patents and advisory relationships, and Cytokinetics advisory work.

Study snapshot

DesignRandomized placebo-controlled human trial
ModelHuman participants
Sample12 older men
InterventionNR 1000 mg/day versus placebo
Duration21 days per treatment period
EndpointsMuscle NAD+ metabolome; mitochondrial bioenergetics; cytokines

What the study showed, in plain terms

NR changed the skeletal-muscle NAD+ metabolome and inflammatory signatures in older men without improving measured mitochondrial bioenergetics.

Key findings

NR changed the skeletal-muscle NAD+ metabolome and inflammatory signatures in older men without improving measured mitochondrial bioenergetics.

What this study can and cannot tell us

Small, short crossover study. Muscle metabolite and transcript changes do not establish greater strength, fitness or lifespan.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology