Tier 2 — strong

Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

Peluso AA, Lundgaard AT, Babaei P, Mousovich-Neto F, Rocha AL, Damgaard MV, Bak EG, Gnanasekaran T, Dollerup OL, Trammell SAJ, Nielsen TS, Kern T, Abild CB, Sulek K, Ma T, Gerhart-Hines Z, Gillum MP, Arumugam M, Ørskov C, McCloskey D, Jessen N, Herrgård MJ, Mori MAS, Treebak JT
npj aging 2023 9; 1; 7

Bibliography

PubMed
PMID 37012386
PubMed Central
PMC10070358
DOI
10.1038/s41514-023-00106-4
Funding
Funding/support listed in the publication: Novo Nordisk Fonden (Novo Nordisk Foundation); Innovationsfonden (Innovation Fund Denmark); Novo Nordisk; Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation).
Competing interests
The authors reported no competing interests.

Study snapshot

DesignSecondary or companion analysis of an existing human intervention
ModelHuman participants, rats, mice and bacterial cultures
SampleHuman supplementation cohort plus separate rat and mouse experiments
InterventionOral NR supplementation in species-specific protocols
Duration12 weeks
EndpointsHuman and rodent microbial composition; adiposity

What the study showed, in plain terms

NR changed intestinal microbial patterns in rodents but did not change the measured human fecal microbial composition.

Key findings

NR changed intestinal microbial patterns in rodents but did not change the measured human fecal microbial composition.

What this study can and cannot tell us

The human component is linked to the prior obesity-trial program. Rodent microbiome changes should not be advertised as a replicated human benefit.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology