Tier 3 — preclinical

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X
Cell metabolism 2020 31; 3; 564-579.e7

Bibliography

PubMed
PMID 32130883
PubMed Central
PMC7194078
DOI
10.1016/j.cmet.2020.02.001
Funding
Indexed grant support includes Intramural NIH HHS. The complete funding declaration is not specified in the accessible abstract.
Competing interests
The authors reported no competing interests.

Study snapshot

DesignPreclinical animal study with supporting assays as applicable
ModelBacteria, cultured cells and mice
SampleBacterial, cellular and microbiota-depleted mouse experiments
InterventionLabeled nicotinamide or NR with microbial pathway manipulation
DurationMetabolic-tracing protocols
EndpointsModel-specific physiological outcomes; Biochemical or functional measures reported in the study

What the study showed, in plain terms

Bacterial conversion of nicotinamide contributed to host NAD+ synthesis and to the effects of oral precursors in the tested systems.

Key findings

Bacterial conversion of nicotinamide contributed to host NAD+ synthesis and to the effects of oral precursors in the tested systems.

What this study can and cannot tell us

The mechanistic work does not prove that any specific probiotic or NR supplement improves clinical gut health.

Related papers in the corpus

Tier 2
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans
Peluso AA et al. · npj aging · 2023

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology