Tier 2 — strong

Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

Dollerup OL, Trammell SAJ, Hartmann B, Holst JJ, Christensen B, Møller N, Gillum MP, Treebak JT, Jessen N
The Journal of clinical endocrinology and metabolism 2019 104; 11; 5703-5714

Bibliography

PubMed
PMID 31390002
DOI
10.1210/jc.2019-01081
Funding
Funding details are not specified in the accessible publication information.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignSecondary endocrine analysis of a randomized placebo-controlled trial
ModelHuman participants
Sample40 men from the 12-week obesity trial
InterventionNR 1000 mg twice daily versus placebo
Duration12 weeks
EndpointsPancreatic hormone responses; incretins; bile acids

What the study showed, in plain terms

This companion analysis found no improvement in pancreatic hormone responses, incretin secretion, beta-cell function or circulating bile acids.

Key findings

This companion analysis found no improvement in pancreatic hormone responses, incretin secretion, beta-cell function or circulating bile acids.

What this study can and cannot tell us

Uses the same clinical cohort as PMID 29992272; it is not an independent replication.

Related papers in the corpus

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Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men
Dollerup OL et al. · The Journal of physiology · 2020
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Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans
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Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology