Tier 1 — highest

Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial

Coby Eelderink, Daan Kremer, Ineke J Riphagen, Tim J Knobbe, Leon J Schurgers, Andreas Pasch, D J Mulder, Eva Corpeleijn, Gerjan Navis, Stephan J L Bakker, Martin H de Borst, Charlotte A Te Velde-Keyzer
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 23(4):520-530

Bibliography

PubMed
PMID 36695702
DOI
10.1016/j.ajt.2022.12.015
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample40 vitamin K-deficient kidney transplant recipients
InterventionMK-7 360 μg/day or placebo
Duration12 weeks
EndpointsSerum calcification propensity; Pulse-wave velocity; dp-ucMGP

What the study showed, in plain terms

This publication examines serum calcification propensity, pulse-wave velocity, dp-ucmgp. Study population or evidence base: 40 vitamin K-deficient kidney transplant recipients. Intervention or exposure: MK-7 360 μg/day or placebo.

Key findings

MK-7 improved vitamin K status and prevented worsening of arterial stiffness, but did not change the primary serum calcification-propensity endpoint.

What this study can and cannot tell us

A small, short study in transplant recipients. Its primary and secondary findings differ, and longer-term clinical outcomes were not established.

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Editorial review

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