Tier 4 — mechanistic

The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial

Koperska A, Miller-Kasprzak E, Seraszek-Jaros A, Musialik K, Bogdański P, Szulińska M
Nutrients 2025 17(22):3585

Bibliography

PubMed
PMID 41305635
PubMed Central
PMC12655164
DOI
10.3390/nu17223585
Funding
Reported funding sources: statutory funding for young researchers–doctoral students. Grant and funder-role details are in the publication.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignCompanion vascular analysis of a double-blind randomized trial
ModelHuman participants; see population
Sample70 adults from the previously reported MAFLD trial
InterventionBerberine 1500 mg/day versus placebo; companion vascular analysis
Duration12 weeks
EndpointsCardiac or vascular outcomes; Inflammatory biomarkers; Adverse events

What the study showed, in plain terms

This report examines vascular measures and VEGF in the cohort whose metabolic results appeared earlier. A rise in VEGF should not automatically be interpreted as cardiovascular protection.

Key findings

  • This report examines vascular measures and VEGF in the cohort whose metabolic results appeared earlier. A rise in VEGF should not automatically be interpreted as cardiovascular protection.

What this study can and cannot tell us

Shared cohort with PMID 39042390; exploratory vascular biomarkers, not cardiovascular event outcomes.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology