Tier 2 — strong

Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis

Hernandez AV, Hwang J, Nasreen I, Sicignano D, Pasupuleti V, Snow-Caroti K, White CM
Journal of dietary supplements 2024 21(2):242-259

Bibliography

PubMed
PMID 37183391
DOI
10.1080/19390211.2023.2212762
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample41 randomized trials; 4838 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

Berberine-containing products improved pooled lipid measures, but effects were less robust for berberine alone than for combinations.

Key findings

  • Berberine-containing products improved pooled lipid measures, but effects were less robust for berberine alone than for combinations.

What this study can and cannot tell us

High heterogeneity and active coingredients, including red yeast rice; whole-product results cannot be assigned to berberine.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology