Tier 2 — strong

Berberine and health outcomes: An umbrella review

Li Z, Wang Y, Xu Q, Ma J, Li X, Yan J, Tian Y, Wen Y, Chen T
Phytotherapy research : PTR 2023 37(5):2051-2066

Bibliography

PubMed
PMID 36999891
DOI
10.1002/ptr.7806
Funding
Indexed support: Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences; National Natural Science Foundation of China. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignOverview of systematic reviews
ModelPublished human studies
Sample11 meta-analyses
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

This umbrella review mapped metabolic, inflammatory and gastrointestinal findings and identified gastrointestinal symptoms as common adverse effects.

Key findings

  • This umbrella review mapped metabolic, inflammatory and gastrointestinal findings and identified gastrointestinal symptoms as common adverse effects.

What this study can and cannot tell us

The underlying meta-analyses need better methods and independent high-quality trials; an umbrella review adds no new randomized participants.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Citation network

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology