Tier 2 — strong

The effect of berberine supplementation on obesity indices: A dose- response meta-analysis and systematic review of randomized controlled trials

Xiong P, Niu L, Talaei S, Kord-Varkaneh H, Clark CCT, Găman MA, Rahmani J, Dorosti M, Mousavi SM, Zarezadeh M, Taghizade-Bilondi H, Zhang J
Complementary therapies in clinical practice 2020 39:101113

Bibliography

PubMed
PMID 32379652
DOI
10.1016/j.ctcp.2020.101113
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample10 studies
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

BMI and waist circumference estimates improved, but pooled body-weight change was not significant.

Key findings

  • BMI and waist circumference estimates improved, but pooled body-weight change was not significant.

What this study can and cannot tell us

Preserve the null weight result; dose-duration meta-regression is observational across trials, not a dosing experiment.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology