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Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects
Drug design, development and therapy
2019
13:129-139
Bibliography
- PubMed
- PMID 30587933
- PubMed Central
- PMC6304249
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Open-label randomized parallel pharmacokinetic study |
|---|---|
| Model | Human participants; see population |
| Sample | 60 healthy Chinese adults across five groups |
| Intervention | Berberine chloride, simvastatin, fenofibrate and selected combinations |
| Duration | Single-dose and 7-day multiple-dose phases |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
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