Tier 1 — highest

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial

Tong Yang, Hualou Wang, Ying Xiong, Chong Chen, Keran Duan, Jingya Jia, Fei Ma
Journal of Alzheimer's disease : JAD 2020 78(4):1509-1518

Bibliography

PubMed
PMID 33164936
DOI
10.3233/JAD-200926
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample183 adults aged 65+ with mild cognitive impairment
InterventionVitamin D 800 IU/day or placebo
Duration12 months
EndpointsCognitive test performance; Leukocyte telomere length; Oxidative-stress and senescence biomarkers

What the study showed, in plain terms

This publication examines cognitive test performance, leukocyte telomere length, oxidative-stress and senescence biomarkers. Study population or evidence base: 183 adults aged 65+ with mild cognitive impairment. Intervention or exposure: Vitamin D 800 IU/day or placebo.

Key findings

The vitamin D group improved on several cognitive tests and showed favorable telomere and oxidative-stress biomarker changes.

What this study can and cannot tell us

A single trial in a selected mild-cognitive-impairment population. The proposed mechanism is not definitive proof of mediation or dementia prevention.

Related papers in the corpus

Tier 1
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Haidong Zhu et al. · The American journal of clinical nutrition · 2025
Tier 1
Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial
Li Chen et al. · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
Tier 1
Increased telomerase activity and vitamin D supplementation in overweight African Americans
H Zhu et al. · International journal of obesity (2005) · 2012
Tier 1
Independent Effects of Vitamin D on Leukocyte Telomere Length and Activity: An RCT in Asian Indian Women With Prediabetes
Surya Prakash Bhatt et al. · Journal of the Endocrine Society · 2025
Tier 1
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial
Samira Rastgoo et al. · Frontiers in immunology · 2025

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research