Tier 1 — highest

Independent Effects of Vitamin D on Leukocyte Telomere Length and Activity: An RCT in Asian Indian Women With Prediabetes

Surya Prakash Bhatt, Shivam Pandey, Anoop Misra
Journal of the Endocrine Society 2025 9(9):bvaf124

Bibliography

PubMed
PMID 40862088
PubMed Central
PMC12375916
DOI
10.1210/jendso/bvaf124
Funding
Support is recorded from Government of India Department of Science and Technology. See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample121 Asian Indian women with prediabetes
InterventionD3 60,000 IU/week for 8 weeks with subsequent maintenance and repletion as required; both groups received calcium
Duration78 weeks
EndpointsLeukocyte telomere length; Telomerase activity

What the study showed, in plain terms

This publication examines leukocyte telomere length, telomerase activity. Study population or evidence base: 121 Asian Indian women with prediabetes. Intervention or exposure: D3 60,000 IU/week for 8 weeks with subsequent maintenance and repletion as required; both groups received calcium.

Key findings

The intervention group showed increased telomere length and telomerase activity over follow-up, supporting further research in women with prediabetes.

What this study can and cannot tell us

A selected population and surrogate biomarkers. These findings do not establish lifespan extension or broad effects in healthy adults.

Related papers in the corpus

Tier 1
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Haidong Zhu et al. · The American journal of clinical nutrition · 2025
Tier 1
Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial
Li Chen et al. · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
Tier 1
Increased telomerase activity and vitamin D supplementation in overweight African Americans
H Zhu et al. · International journal of obesity (2005) · 2012
Tier 1
Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
Tong Yang et al. · Journal of Alzheimer's disease : JAD · 2020
Tier 1
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial
Samira Rastgoo et al. · Frontiers in immunology · 2025

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research