Tier 1 — highest

Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial

Li Chen, Yanbin Dong, Jigar Bhagatwala, Anas Raed, Ying Huang, Haidong Zhu
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 74(1):91-98

Bibliography

PubMed
PMID 30256915
PubMed Central
PMC6612014
DOI
10.1093/gerona/gly223
Funding
Support is recorded from NHLBI NIH HHS. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignExploratory epigenetic analysis of a randomized dose-ranging trial
ModelHuman participants
Sample51 participants from a 70-person trial
InterventionD3 600, 2,000 or 4,000 IU/day, or placebo
Duration16 weeks
EndpointsHorvath and Hannum DNA methylation ages

What the study showed, in plain terms

This publication examines horvath and hannum dna methylation ages. Study population or evidence base: 51 participants from a 70-person trial. Intervention or exposure: D3 600, 2,000 or 4,000 IU/day, or placebo.

Key findings

Selected higher-dose groups showed favorable changes in epigenetic-age estimates compared with placebo. Results differed between the two clocks.

What this study can and cannot tell us

Small exploratory sample, short duration and multiple comparisons. Changes in clock estimates do not establish clinical rejuvenation or longer lifespan.

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