Tier 4 — mechanistic
Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
Planta Medica
1995
61(3):213-216
Bibliography
- PubMed
- PMID 7617761
- Funding
- Not reported in the indexed record reviewed.
- Competing interests
- Not reported in the indexed record reviewed.
Study snapshot
| Design | Receptor-binding experiments with acute mouse behavioral testing |
|---|---|
| Model | Central benzodiazepine-receptor assays and mice |
| Sample | Exact total sample size was not reported in the PubMed abstract. |
| Intervention | Isolated apigenin; receptor-binding assays and acute administration in mice across behavioral doses |
| Duration | Acute preclinical experiments |
| Endpoints | Flunitrazepam binding at central benzodiazepine receptors; Elevated plus-maze behavior; Locomotor activity; Hole-board behavior; Muscle relaxation; Anticonvulsant activity |
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