Tier 2 — strong

Acute effect of betaine supplementation on muscular endurance during resistance exercise in trained men: a pilot and randomized study

Matheus Dantas, Victor Sabino de Queiros, Tatiane Andreza Lima da Silva, Alana Monteiro Bispo da Silva, Leonardo de Souza Fortes, Jason Cholewa, Anna Luiza Vasconcelos de Oliveira, Breno Guilherme de Araújo Tinôco Cabral
Journal of Trainology 2021 10(2):25-29

Bibliography

DOI
10.17338/trainology.10.2_25
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignRandomized crossover controlled trial
ModelHuman participants
Sample10 resistance-trained men
InterventionAcute betaine versus placebo; dose not stated in the publisher abstract
DurationTwo acute exercise sessions separated by 48 hours
EndpointsBench-press endurance; Training volume

What the study showed, in plain terms

Published in 2021, this source examined exercise performance and body composition. Design: Randomized crossover controlled trial. Sample/model: 10 resistance-trained men. The exposure or intervention was Acute betaine versus placebo; dose not stated in the publisher abstract. Follow-up or treatment period: Two acute exercise sessions separated by 48 hours.

Betaine did not significantly improve bench-press repetitions to failure across three sets.

A small acute pilot with a short crossover interval; does not resolve longer-term supplementation effects.

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Key findings

  • Betaine did not significantly improve bench-press repetitions to failure across three sets.
  • The recorded outcome domains were Bench-press endurance; Training volume.
  • The result applies to the tested exposure: Acute betaine versus placebo; dose not stated in the publisher abstract; Two acute exercise sessions separated by 48 hours.

What this study can and cannot tell us

  • A small acute pilot with a short crossover interval; does not resolve longer-term supplementation effects.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology