Tier 2 — strong

The effects of betaine supplementation on fluid balance and heat tolerance during passive heat stress in men

Brandon D Willingham, Liliana I Rentería, Tristan J Ragland, Michael J Ormsbee
Physiological reports 2023 11(16):e15792

Bibliography

PubMed
PMID 37604644
PubMed Central
PMC10442523
DOI
10.14814/phy2.15792
Funding
Reported funding/support: NOW FoodsRF04017
Competing interests
Reported disclosure: All other authors have no competing interests to declare.

Study snapshot

DesignRandomized crossover controlled trial
ModelHuman participants
Sample11 recreationally active men
InterventionBetaine 50 mg/kg twice daily versus placebo
Duration7 days, followed by passive heat exposure
EndpointsFluid balance; Core temperature; Heat tolerance

What the study showed, in plain terms

Published in 2023, this source examined exercise performance and body composition. Design: Randomized crossover controlled trial. Sample/model: 11 recreationally active men. The exposure or intervention was Betaine 50 mg/kg twice daily versus placebo. Follow-up or treatment period: 7 days, followed by passive heat exposure.

Fluid-balance measures, plasma-volume responses and core-temperature changes did not differ meaningfully from placebo.

Small short experiment using passive heat; results cannot establish heat protection during occupational or athletic exertion.

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Key findings

  • Fluid-balance measures, plasma-volume responses and core-temperature changes did not differ meaningfully from placebo.
  • The recorded outcome domains were Fluid balance; Core temperature; Heat tolerance.
  • The result applies to the tested exposure: Betaine 50 mg/kg twice daily versus placebo; 7 days, followed by passive heat exposure.

What this study can and cannot tell us

  • Small short experiment using passive heat; results cannot establish heat protection during occupational or athletic exertion.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology