Tier 4 — mechanistic

Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods

Dejan Dobrijević, Kristian Pastor, Nataša Nastić, Fatih Özogul, Jelena Krulj, Bojana Kokić, Elena Bartkiene, João Miguel Rocha, Jovana Kojić
Molecules (Basel, Switzerland) 2023 28(12):4824

Bibliography

PubMed
PMID 37375378
PubMed Central
PMC10302777
DOI
10.3390/molecules28124824
Funding
Reported funding/support: Ministry of Science, Technological Development, and Innovation of the Republic of Serbia451-03-47/2023-01/200222451-03-47/2023-01/200134COST Action 18101 SOURDOMICS—Sourdough Biotechnology Network towards novel, healthier, and sustainable food and bioprocessesThis work received financial support from the Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (Program no. 451-03-47/2023-01/200222 and 451-03-47/2023-01/200134). It also received financial support for the article processing charges from the COST Action 18101 SOURDOMICS—Sourdough Biotechnology Network towards novel, healthier, and sustainable food and bioprocesses.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignNarrative review
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2023, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Reviews natural food sources, metabolism, extraction and analytical methods for betaine as a food ingredient.

A broad ingredient review combining different models; proposed health applications require direct human confirmation.

Continue with TMG Data Center

Continue with Foods High in Betaine: TMG Amounts and Practical Portions

Key findings

  • Reviews natural food sources, metabolism, extraction and analytical methods for betaine as a food ingredient.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • A broad ingredient review combining different models; proposed health applications require direct human confirmation.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Betaine in human nutrition
Stuart A S Craig et al. · The American journal of clinical nutrition · 2004
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Choline and betaine in health and disease
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology