Tier 2 — strong

Different choline supplement metabolism in adults using deuterium labelling

Katrin A Böckmann, Axel R Franz, Anna Shunova, Michaela Minarski, Cornelia Wiechers, Christian F Poets, Wolfgang Bernhard
European journal of nutrition 2023 62(4):1795-1807

Bibliography

PubMed
PMID 36840817
PubMed Central
PMC10195734
DOI
10.1007/s00394-023-03121-z
Funding
Reported funding/support: HiPP-Werk Georg Hipp OHG Ministry of Economy of the State of Baden-Württemberg AsphyxDx, Az. 35-4223.10/17 Universitätsklinikum Tübingen (8868)Open Access funding enabled and organized by Projekt DEAL.
Competing interests
Reported disclosure: The authors declare that they have no conflict of interest to disclose. Trial Registration: This trial was registered at https://drks.de/drks_web/ trial ID DRKS00020498.

Study snapshot

DesignRandomized isotope-labelled crossover trial
ModelHuman participants
Sample6 healthy men
InterventionFour deuterium-labelled choline forms at 2.7 mg/kg choline equivalent
DurationSampling through 7 days; 6 weeks between doses
EndpointsLabelled betaine; Choline metabolism; TMAO

What the study showed, in plain terms

Published in 2023, this source examined food sources, absorption and nutrient metabolism. Design: Randomized isotope-labelled crossover trial. Sample/model: 6 healthy men. The exposure or intervention was Four deuterium-labelled choline forms at 2.7 mg/kg choline equivalent. Follow-up or treatment period: Sampling through 7 days; 6 weeks between doses.

Choline forms produced different timing and metabolite patterns; phosphatidylcholine generated little labelled TMAO in this experiment.

Tracer physiology in six men; not a direct trial of betaine supplementation or long-term cardiovascular outcomes.

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Key findings

  • Choline forms produced different timing and metabolite patterns; phosphatidylcholine generated little labelled TMAO in this experiment.
  • The recorded outcome domains were Labelled betaine; Choline metabolism; TMAO.
  • The result applies to the tested exposure: Four deuterium-labelled choline forms at 2.7 mg/kg choline equivalent; Sampling through 7 days; 6 weeks between doses.

What this study can and cannot tell us

  • Tracer physiology in six men; not a direct trial of betaine supplementation or long-term cardiovascular outcomes.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology