Tier 4 — mechanistic

Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies

Krystyna Yeroshkina, Zoia Rossokha, Liliya Fishchuk, Nataliia Gorovenko
Nutrition reviews 2023 81(6):716-726

Bibliography

PubMed
PMID 36164833
DOI
10.1093/nutrit/nuac084
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignNarrative review
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2023, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Examines how betaine and BHMT variation might interact with folate-related metabolism.

Theoretical genotype-based proposals require clinical validation and do not establish routine genetic testing or universal TMG use.

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Key findings

  • Examines how betaine and BHMT variation might interact with folate-related metabolism.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • Theoretical genotype-based proposals require clinical validation and do not establish routine genetic testing or universal TMG use.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Beneficial Effects of Betaine: A Comprehensive Review
Madan Kumar Arumugam et al. · Biology · 2021
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Betaine in human nutrition
Stuart A S Craig et al. · The American journal of clinical nutrition · 2004
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Choline and betaine in health and disease
Per Magne Ueland et al. · Journal of inherited metabolic disease · 2011

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology