Tier 2 — strong

The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males

Emilia Zawieja, Krzysztof Durkalec-Michalski, Agata Muzsik-Kazimierska, Agata Chmurzynska
Metabolites 2022 12(8):731

Bibliography

PubMed
PMID 36005603
PubMed Central
PMC9415743
DOI
10.3390/metabo12080731
Funding
Reported funding/support: Polish National Science Centre2017/27/N/NZ9/00750The present research was funded by the Polish National Science Centre under Grant no. 2017/27/N/NZ9/00750.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignRandomized crossover controlled trial
ModelHuman participants
Sample43 male completers from 55 recruited
InterventionBetaine 2.5 or 5 g/day versus placebo
Duration21 days per treatment; 21-day washout
EndpointsHomocysteine; Lipids; Inflammation

What the study showed, in plain terms

Published in 2022, this source examined homocysteine, methylation and vascular function. Design: Randomized crossover controlled trial. Sample/model: 43 male completers from 55 recruited. The exposure or intervention was Betaine 2.5 or 5 g/day versus placebo. Follow-up or treatment period: 21 days per treatment; 21-day washout.

Homocysteine decreased from about 17.1 to 15.6 micromol/L during betaine treatment, while measured lipids, cytokines and liver enzymes showed no significant adverse change.

Short duration and healthy active men. Companion reports from this registered trial are not independent replication. Related reports from the same research program may share participants. Read trial registration and linked companion reports before counting independent studies.

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Key findings

  • Homocysteine decreased from about 17.1 to 15.6 micromol/L during betaine treatment, while measured lipids, cytokines and liver enzymes showed no significant adverse change.
  • The recorded outcome domains were Homocysteine; Lipids; Inflammation.
  • The result applies to the tested exposure: Betaine 2.5 or 5 g/day versus placebo; 21 days per treatment; 21-day washout.

What this study can and cannot tell us

  • Short duration and healthy active men. Companion reports from this registered trial are not independent replication. Related reports from the same research program may share participants. Read trial registration and linked companion reports before counting independent studies.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology