Tier 4 — mechanistic

The Role of Betaine in Patients With Chronic Kidney Disease: a Narrative Review

Livia Alvarenga, Maíra S Ferreira, Julie A Kemp, Denise Mafra
Current nutrition reports 2022 11(3):395-406

Bibliography

PubMed
PMID 35792998
DOI
10.1007/s13668-022-00426-z
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignNarrative review
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2022, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Reviews betaine biology, disease-associated blood levels and experimental kidney-protective findings.

CKD changes metabolite handling; biomarker associations and animal findings are not evidence for unsupervised treatment in kidney disease.

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Key findings

  • Reviews betaine biology, disease-associated blood levels and experimental kidney-protective findings.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • CKD changes metabolite handling; biomarker associations and animal findings are not evidence for unsupervised treatment in kidney disease.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Beneficial Effects of Betaine: A Comprehensive Review
Madan Kumar Arumugam et al. · Biology · 2021
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Betaine in human nutrition
Stuart A S Craig et al. · The American journal of clinical nutrition · 2004
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Choline and betaine in health and disease
Per Magne Ueland et al. · Journal of inherited metabolic disease · 2011

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology