Tier 2 — strong

A wheat aleurone-rich diet improves oxidative stress but does not influence glucose metabolism in overweight/obese individuals: Results from a randomized controlled trial

Giuseppina Costabile, Marilena Vitale, Giuseppe Della Pepa, Paola Cipriano, Claudia Vetrani, Roberta Testa, Pedro Mena, Letizia Bresciani, Michele Tassotti, Luca Calani, Daniele Del Rio, Furio Brighenti, Raffaele Napoli, Angela A Rivellese, Gabriele Riccardi, Rosalba Giacco
Nutrition, metabolism, and cardiovascular diseases : NMCD 2022 32(3):715-726

Bibliography

PubMed
PMID 35123855
DOI
10.1016/j.numecd.2021.12.016
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
Reported disclosure: Gabriele Riccardi is member of the Health and Wellbeing Advisory Board of the Barilla company; remuneration for this activity goes to his University Department. All other authors declare no conflict of interest.

Study snapshot

DesignRandomized crossover controlled trial
ModelHuman participants
Sample23 adults with overweight or obesity
InterventionAleurone-rich versus refined-wheat diets
Duration8 weeks per diet
EndpointsOxidative stress; Betaine; Glucose metabolism

What the study showed, in plain terms

Published in 2022, this source examined food sources, absorption and nutrient metabolism. Design: Randomized crossover controlled trial. Sample/model: 23 adults with overweight or obesity. The exposure or intervention was Aleurone-rich versus refined-wheat diets. Follow-up or treatment period: 8 weeks per diet.

The aleurone diet raised plasma betaine and lowered an oxidative-stress marker but did not improve glucose, insulin, triglycerides or homocysteine.

Whole-food intervention with several active constituents and multiple endpoints; clinical disease benefit was not demonstrated.

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Key findings

  • The aleurone diet raised plasma betaine and lowered an oxidative-stress marker but did not improve glucose, insulin, triglycerides or homocysteine.
  • The recorded outcome domains were Oxidative stress; Betaine; Glucose metabolism.
  • The result applies to the tested exposure: Aleurone-rich versus refined-wheat diets; 8 weeks per diet.

What this study can and cannot tell us

  • Whole-food intervention with several active constituents and multiple endpoints; clinical disease benefit was not demonstrated.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology