Tier 2 — strong

Ergogenic effects of betaine supplementation on strength and power performance

Elaine C Lee, Carl M Maresh, William J Kraemer, Linda M Yamamoto, Disa L Hatfield, Brooke L Bailey, Lawrence E Armstrong, Jeff S Volek, Brendon P McDermott, Stuart As Craig
Journal of the International Society of Sports Nutrition 2010 7:27

Bibliography

PubMed
PMID 20642826
PubMed Central
PMC2915951
DOI
10.1186/1550-2783-7-27
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
Reported disclosure: Competing interestsThe first nine authors, all associated with the University of Connecticut at the time of this study, declare that they have no competing interests. SASC is employed by Danisco A/S, the company that funded this study. Publication of these findings should not be viewed as endorsement by the investigators, the University of Connecticut, or the editorial board of the Journal of the International Society of Sport Nutrition.

Study snapshot

DesignRandomized crossover controlled trial
ModelHuman participants
Sample12 resistance-trained men
InterventionBetaine 1.25 g twice daily versus placebo
Duration14 days per treatment
EndpointsStrength; Power; Exercise fatigue

What the study showed, in plain terms

Published in 2010, this source examined exercise performance and body composition. Design: Randomized crossover controlled trial. Sample/model: 12 resistance-trained men. The exposure or intervention was Betaine 1.25 g twice daily versus placebo. Follow-up or treatment period: 14 days per treatment.

Some bench-throw, isometric force and jump outcomes improved, while jump-squat power and repetition counts did not consistently differ.

Very small sample, short duration and several tested outcomes; does not establish long-term muscle gain.

Continue with TMG Data Center

Continue with Betaine Anhydrous Pre-Workout: Performance, Dose and Evidence

Key findings

  • Some bench-throw, isometric force and jump outcomes improved, while jump-squat power and repetition counts did not consistently differ.
  • The recorded outcome domains were Strength; Power; Exercise fatigue.
  • The result applies to the tested exposure: Betaine 1.25 g twice daily versus placebo; 14 days per treatment.

What this study can and cannot tell us

  • Very small sample, short duration and several tested outcomes; does not establish long-term muscle gain.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Effects of chronic betaine supplementation on exercise performance: Systematic review and meta-analysis
Emilia Zawieja et al. · Journal of sports sciences · 2024
Tier 2
Effects of betaine supplementation on endurance exercise performance: a systematic review
Marie Stella Louise Perreras et al. · Physical activity and nutrition · 2025
Tier 1
Betaine supplementation fails to improve body composition: a systematic review and meta-analysis
Damoon Ashtary-Larky et al. · The British journal of nutrition · 2022
Tier 2
Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery
David C Nieman et al. · Nutrients · 2025
Tier 2
Betaine Supplementation Does Not Improve Muscle Hypertrophy or Strength Following 6 Weeks of Cross-Fit Training
Tatiana Moro et al. · Nutrients · 2020

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology