Tier 4 — mechanistic

Quantitative measurement of betaine and free choline in plasma, cereals and cereal products by isotope dilution LC-MS/MS

Stephen J Bruce, Philippe A Guy, Serge Rezzi, Alastair B Ross
Journal of agricultural and food chemistry 2010 58(4):2055-2061

Bibliography

PubMed
PMID 20102202
DOI
10.1021/jf903930k
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignAnalytical validation and food-composition study
ModelFood, milk or laboratory samples
Sample47 human plasma samples, 32 cereal flours/fractions and 51 cereal products
InterventionLC-MS/MS measurement of betaine and free choline
DurationCross-sectional laboratory sampling
EndpointsAnalytical measurement; Food betaine

What the study showed, in plain terms

Published in 2010, this source examined food sources, absorption and nutrient metabolism. It examined LC-MS/MS measurement of betaine and free choline. The source describes 47 human plasma samples, 32 cereal flours/fractions and 51 cereal products.

The method quantified betaine in foods and plasma; whole-grain wheat and rye products were notable food sources.

Method validation and composition data do not establish supplement efficacy or clinical deficiency thresholds.

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Continue with Foods High in Betaine: TMG Amounts and Practical Portions

Key findings

  • The method quantified betaine in foods and plasma; whole-grain wheat and rye products were notable food sources.
  • The recorded outcome domains were Analytical measurement; Food betaine.

What this study can and cannot tell us

  • Method validation and composition data do not establish supplement efficacy or clinical deficiency thresholds.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Alastair B Ross et al. · Food chemistry · 2014
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology