Tier 2 — strong

Effect of betaine supplementation on power performance and fatigue

Jay R Hoffman, Nicholas A Ratamess, Jie Kang, Stefanie L Rashti, Avery D Faigenbaum
Journal of the International Society of Sports Nutrition 2009 6:7

Bibliography

PubMed
PMID 19250531
PubMed Central
PMC2651845
DOI
10.1186/1550-2783-6-7
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
Reported disclosure: Competing interestsDanisco-USA, (Ardsley, NY) provided funding for this project. All researchers involved collected, analyzed, and interpreted the results from this study and have no financial interests concerning the outcome of this investigation. Publication of these findings should not be viewed as endorsement by the investigators, The College of New Jersey or the editorial board of the Journal of International Society of Sports Nutrition.

Study snapshot

DesignRandomized controlled trial
ModelHuman participants
Sample24 active college-age men
InterventionBetaine versus placebo; 2.5 g/day in the full-text protocol
Duration15-day supplementation protocol
EndpointsMuscular endurance; Anaerobic power

What the study showed, in plain terms

Published in 2009, this source examined exercise performance and body composition. Design: Randomized controlled trial. Sample/model: 24 active college-age men. The exposure or intervention was Betaine versus placebo; 2.5 g/day in the full-text protocol. Follow-up or treatment period: 15-day supplementation protocol.

Selected squat endurance measures improved, but jump, bench-throw and Wingate power did not differ between groups.

Small short trial with numerous performance outcomes. Benefits were task-specific rather than a general increase in power.

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Key findings

  • Selected squat endurance measures improved, but jump, bench-throw and Wingate power did not differ between groups.
  • The recorded outcome domains were Muscular endurance; Anaerobic power.
  • The result applies to the tested exposure: Betaine versus placebo; 2.5 g/day in the full-text protocol; 15-day supplementation protocol.

What this study can and cannot tell us

  • Small short trial with numerous performance outcomes. Benefits were task-specific rather than a general increase in power.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology