Tier 2 — strong

Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study

Aurelian Bidulescu, Lloyd E Chambless, Anna Maria Siega-Riz, Steven H Zeisel, Gerardo Heiss
Nutrition journal 2009 8:14

Bibliography

PubMed
PMID 19232103
PubMed Central
PMC2654540
DOI
10.1186/1475-2891-8-14
Funding
Indexed grant support: N01 HC055016 — NHLBI NIH HHS — United States; N01 HC055019 — NHLBI NIH HHS — United States; DK55865 — NIDDK NIH HHS — United States; N01-HC-55016 — NHLBI NIH HHS — United States; N01 HC055015 — NHLBI NIH HHS — United States; N01-HC-55021 — NHLBI NIH HHS — United States; N01-HC-55019 — NHLBI NIH HHS — United States; L60 MD002938 — NIMHD NIH HHS — United States; N01-HC-55015 — NHLBI NIH HHS — United States; N01 HC055018 — NHLBI NIH HHS — United States; T32 DK007686 — NIDDK NIH HHS — United States; P30 DK056350 — NIDDK NIH HHS — United States; N01 HC055022 — NHLBI NIH HHS — United States; P01 AG009525 — NIA NIH HHS — United States; N01-HC-55022 — NHLBI NIH HHS — United States; R01 DK055865 — NIDDK NIH HHS — United States; N01 HC055021 — NHLBI NIH HHS — United States; N01 HC055020 — NHLBI NIH HHS — United States; DK56350 — NIDDK NIH HHS — United States; DK07686 — NIDDK NIH HHS — United States; UL1 TR000454 — NCATS NIH HHS — United States; N01-HC-55020 — NHLBI NIH HHS — United States; R24 HD050924 — NICHD NIH HHS — United States; N01-HC-55018 — NHLBI NIH HHS — United States; T32 HL007055 — NHLBI NIH HHS — United States; HL07055 — NHLBI NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
Reported disclosure: Competing interestsDr. S. H. Zeisel received grant support from Mead Johnson Nutritionals and the Egg Nutrition Research Center for studies other than those described in this paper. The other authors declare that they have no competing interests.

Study snapshot

DesignDietary reliability study
ModelHuman participants
Sample1004 ARIC participants in the reliability sample
InterventionRepeat food-frequency estimates of choline and related methyl donors
DurationApproximately 3-year repeat interval
EndpointsDietary repeatability; Measurement error

What the study showed, in plain terms

Published in 2009, this source examined food sources, absorption and nutrient metabolism. Design: Dietary reliability study. Sample/model: 1004 ARIC participants in the reliability sample. The exposure or intervention was Repeat food-frequency estimates of choline and related methyl donors. Follow-up or treatment period: Approximately 3-year repeat interval.

Dietary measurement reliability was moderate and error was substantial, including for combined choline-plus-betaine intake.

Shows uncertainty in nutrient-exposure measurement; a low estimated intake is not itself proof of deficiency or benefit from treatment.

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Key findings

  • Dietary measurement reliability was moderate and error was substantial, including for combined choline-plus-betaine intake.
  • The recorded outcome domains were Dietary repeatability; Measurement error.
  • The result applies to the tested exposure: Repeat food-frequency estimates of choline and related methyl donors; Approximately 3-year repeat interval.

What this study can and cannot tell us

  • Shows uncertainty in nutrient-exposure measurement; a low estimated intake is not itself proof of deficiency or benefit from treatment.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology