Tier 4 — mechanistic

Betaine: a key modulator of one-carbon metabolism and homocysteine status

Per Magne Ueland, Pål I Holm, Steinar Hustad
Clinical chemistry and laboratory medicine 2005 43(10):1069-1075

Bibliography

PubMed
PMID 16197300
DOI
10.1515/CCLM.2005.187
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignNarrative review
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2005, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Describes the relationship between betaine status, folate-dependent pathways and fasting/post-load homocysteine.

A biochemical review with important nutritional context; lower homocysteine alone is not proof of cardiovascular prevention.

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Key findings

  • Describes the relationship between betaine status, folate-dependent pathways and fasting/post-load homocysteine.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • A biochemical review with important nutritional context; lower homocysteine alone is not proof of cardiovascular prevention.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Citation network

Articles citing this research paper

4 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology