Tier 2 — strong

Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel (Main Components: Onion Extract Quercetin) for the Treatment of Rosacea

Zining Xu, Biao Yu, Yuxin Qing, Shuhong Ye, Bingyang Xu, Yuanqin Wang, Bin Zhao, Hong Sun, Na Wu, Jiawen Wu
Journal of cosmetic dermatology 2025 24(4):e70129

Bibliography

PubMed
PMID 40177799
PubMed Central
PMC11966348
DOI
10.1111/jocd.70129
Funding
Reported funding/support: Xi’an Jiaotong University Free Exploration Project2024JC‐YBMS‐632Zhejiang Medical Technology Development Company crosswise tasks2023HXKT014
Competing interests
Reported disclosure: The authors declare no conflicts of interest.

Study snapshot

DesignRandomized prospective controlled topical trial
ModelHuman intervention research
Sample82 patients with papulopustular rosacea
InterventionCompound heparin sodium/allantoin/onion-extract gel versus comparison treatment
Duration12 weeks
EndpointsSymptoms and quality of life

What the study showed, in plain terms

Published in 2025, this source examined skin and topical formulations. Design: Randomized prospective controlled topical trial. Sample/model: 82 patients with papulopustular rosacea. The exposure or intervention was Compound heparin sodium/allantoin/onion-extract gel versus comparison treatment. Follow-up or treatment period: 12 weeks.

The compound gel improved erythema, discomfort, skin hydration and barrier measurements relative to comparison treatment.

Topical multi-ingredient product. Effects cannot be isolated to quercetin or extrapolated to an oral supplement.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The compound gel improved erythema, discomfort, skin hydration and barrier measurements relative to comparison treatment.
  • The recorded outcome domains were Symptoms and quality of life.
  • The result applies to the tested exposure: Compound heparin sodium/allantoin/onion-extract gel versus comparison treatment; 12 weeks.

What this study can and cannot tell us

  • Topical multi-ingredient product. Effects cannot be isolated to quercetin or extrapolated to an oral supplement.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology