Tier 2 — strong

Nano-hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study

Giuseppe Gallelli, Erika Cione, Raffaele Serra, Antonio Leo, Rita Citraro, Pietro Matricardi, Chiara Di Meo, Francesco Bisceglia, Maria C Caroleo, Sonia Basile, Luca Gallelli
International wound journal 2020 17(2):485-490

Bibliography

PubMed
PMID 31876118
PubMed Central
PMC7948574
DOI
10.1111/iwj.13299
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare no conflicts of interests.

Study snapshot

DesignRandomized active-comparator topical pilot trial
ModelHuman intervention research
Sample56 adults with diabetes and lower-limb wounds
InterventionQuercetin/oleic-acid nanohydrogel versus 0.2% hyaluronic acid, added to wound care
DurationHealing followed; exact schedule not stated in abstract
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2020, this source examined skin and topical formulations. Design: Randomized active-comparator topical pilot trial. Sample/model: 56 adults with diabetes and lower-limb wounds. The exposure or intervention was Quercetin/oleic-acid nanohydrogel versus 0.2% hyaluronic acid, added to wound care. Follow-up or treatment period: Healing followed; exact schedule not stated in abstract.

The nanohydrogel group had shorter wound-healing time than the comparator.

Topical combination with an active comparator. The result does not establish oral-quercetin wound healing.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The nanohydrogel group had shorter wound-healing time than the comparator.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The result applies to the tested exposure: Quercetin/oleic-acid nanohydrogel versus 0.2% hyaluronic acid, added to wound care; Healing followed; exact schedule not stated in abstract.

What this study can and cannot tell us

  • Topical combination with an active comparator. The result does not establish oral-quercetin wound healing.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology