Tier 1 — highest

The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials

Seyyed Mostafa Arabi, Mostafa Shahraki Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Mohsen Maleki, Vasily N Sukhorukov, Amirhossein Sahebkar
Phytotherapy research : PTR 2023 37(11):5080-5091

Bibliography

PubMed
PMID 37654199
DOI
10.1002/ptr.7971
Funding
Indexed grant support: 22-15-00064 — Russian Science Foundation. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignUmbrella review of randomized-trial meta-analyses
ModelHuman evidence synthesis
Sample5 meta-analyses covering 18 eligible trials, plus 5 additional trials
InterventionQuercetin supplementation across trial-specific regimens
DurationLiterature search to the review cutoff
EndpointsBlood pressure; Glucose and insulin measures

What the study showed, in plain terms

Published in 2023, this source examined cardiovascular and metabolic health. Its evidence base was 5 meta-analyses covering 18 eligible trials, plus 5 additional trials. It evaluated Quercetin supplementation across trial-specific regimens across Literature search to the review cutoff.

Systolic pressure and insulin decreased modestly; most other cardiometabolic outcomes did not improve.

Very low-to-moderate certainty and substantial heterogeneity. Overlapping meta-analyses should not be counted as independent confirmations or participant populations.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Weight Loss, Blood Sugar and Fatty Liver: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Systolic pressure and insulin decreased modestly; most other cardiometabolic outcomes did not improve.
  • The recorded outcome domains were Blood pressure; Glucose and insulin measures.
  • This synthesis reuses the included study populations; it is not an additional randomized participant cohort.

What this study can and cannot tell us

  • Very low-to-moderate certainty and substantial heterogeneity. Overlapping meta-analyses should not be counted as independent confirmations or participant populations.
  • Pooled estimates depend on the included trials and may share participants with companion publications or other reviews. A statistically significant surrogate outcome does not establish disease prevention.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis
Joanna Popiolek-Kalisz et al. · Current problems in cardiology · 2022
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The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials
Reza Tabrizi et al. · Critical reviews in food science and nutrition · 2020
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Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis
Haohai Huang et al. · Nutrition reviews · 2020

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology