Tier 1 — highest

The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Reza Tabrizi, Omid Reza Tamtaji, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Akbari, Seyed Taghi Heydari, Ehsan Dadgostar, Zatollah Asemi
Critical reviews in food science and nutrition 2020 60(11):1855-1868

Bibliography

PubMed
PMID 31017459
DOI
10.1080/10408398.2019.1604491
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignSystematic review and meta-analysis of randomized trials
ModelHuman evidence synthesis
Sample16 trials in metabolic syndrome and related disorders
InterventionQuercetin supplementation at trial-specific doses
DurationSearches through November 2018
EndpointsLipid measurements; Inflammatory measures

What the study showed, in plain terms

Published in 2020, this source examined cardiovascular and metabolic health. Its evidence base was 16 trials in metabolic syndrome and related disorders. It evaluated Quercetin supplementation at trial-specific doses across Searches through November 2018.

Total cholesterol, LDL, and CRP decreased in pooled analyses; triglycerides, HDL, IL-6, and TNF-alpha did not.

Very high heterogeneity for several outcomes and differences from other pooled reviews limit confidence in a consistent clinical effect.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Weight Loss, Blood Sugar and Fatty Liver: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Total cholesterol, LDL, and CRP decreased in pooled analyses; triglycerides, HDL, IL-6, and TNF-alpha did not.
  • The recorded outcome domains were Lipid measurements; Inflammatory measures.
  • This synthesis reuses the included study populations; it is not an additional randomized participant cohort.

What this study can and cannot tell us

  • Very high heterogeneity for several outcomes and differences from other pooled reviews limit confidence in a consistent clinical effect.
  • Pooled estimates depend on the included trials and may share participants with companion publications or other reviews. A statistically significant surrogate outcome does not establish disease prevention.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis
Joanna Popiolek-Kalisz et al. · Current problems in cardiology · 2022
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Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis
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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology