Tier 3 — preclinical

Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer

Tia Okselni, Abdi Wira Septama, Dian Juliadmi, Rizna Triana Dewi, Marissa Angelina, Tri Yuliani, Grace Serepina Saragih, Ariyanti Saputri
Naunyn-Schmiedeberg's archives of pharmacology 2025 398(5):5011-5055

Bibliography

PubMed
PMID 39738831
DOI
10.1007/s00210-024-03722-3
Funding
Indexed grant support: Grant no. 5/III.9/HK/2024 — Rumah Program Organisasi Riset Kesehatan - BRIN. The indexed list may not contain the complete funding declaration.
Competing interests
Reported disclosure: Declarations. Competing interests: The authors declare no competing interests.

Study snapshot

DesignSystematic review and meta-analysis of experimental skin research
ModelPreclinical evidence synthesis
Sample65 studies included in quantitative synthesis
InterventionQuercetin across heterogeneous skin, wound, pigmentation, and tumor models
DurationLiterature available at the review cutoff
EndpointsInflammatory measures; Oxidative-stress measures

What the study showed, in plain terms

Published in 2025, this source examined skin and topical formulations. Design: Systematic review and meta-analysis of experimental skin research. Sample/model: 65 studies included in quantitative synthesis. The exposure or intervention was Quercetin across heterogeneous skin, wound, pigmentation, and tumor models. Follow-up or treatment period: Literature available at the review cutoff.

Pooled experimental outcomes favored selected oxidative, inflammatory, wound, and pigmentation measures.

The abstract pools biological endpoints across heterogeneous models without establishing human efficacy. It does not demonstrate cosmetic anti-aging, cancer prevention, or wound healing from oral capsules.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Pooled experimental outcomes favored selected oxidative, inflammatory, wound, and pigmentation measures.
  • The recorded outcome domains were Inflammatory measures; Oxidative-stress measures.
  • The result applies to the tested exposure: Quercetin across heterogeneous skin, wound, pigmentation, and tumor models; Literature available at the review cutoff.

What this study can and cannot tell us

  • The abstract pools biological endpoints across heterogeneous models without establishing human efficacy. It does not demonstrate cosmetic anti-aging, cancer prevention, or wound healing from oral capsules.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology