Tier 2 — strong

The effect of quercetin supplementation on selected markers of inflammation and oxidative stress

Gholamreza Askari, Reza Ghiasvand, Awat Feizi, Syed Mustafa Ghanadian, Jahangir Karimian
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2012 17(7):637-41

Bibliography

PubMed
PMID 23798923
PubMed Central
PMC3685779
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: None declared

Study snapshot

DesignRandomized double-blind placebo-controlled four-arm athlete biomarker trial
ModelHuman intervention research
Sample60 young adults
InterventionQuercetin 500 mg/day with or without vitamin C 250 mg/day, vitamin C alone, or placebo
Duration8 weeks
EndpointsInflammatory measures; Oxidative-stress measures

What the study showed, in plain terms

Published in 2012, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled four-arm athlete biomarker trial. Sample/model: 60 young adults. The exposure or intervention was Quercetin 500 mg/day with or without vitamin C 250 mg/day, vitamin C alone, or placebo. Follow-up or treatment period: 8 weeks.

Selected inflammatory and oxidative measures favored the combination, while several comparisons were only marginally significant.

Small arms, multiple comparisons, and thresholds as high as p<0.1 limit confidence. Related 60-person athlete reports may share the same cohort.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Selected inflammatory and oxidative measures favored the combination, while several comparisons were only marginally significant.
  • The recorded outcome domains were Inflammatory measures; Oxidative-stress measures.
  • The result applies to the tested exposure: Quercetin 500 mg/day with or without vitamin C 250 mg/day, vitamin C alone, or placebo; 8 weeks.

What this study can and cannot tell us

  • Small arms, multiple comparisons, and thresholds as high as p<0.1 limit confidence. Related 60-person athlete reports may share the same cohort.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Companion or correction records are linked below. They should not be counted automatically as independent replications; see the individual source notes for the relationship.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Quercetin and vitamin C supplementation: effects on lipid profile and muscle damage in male athletes
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The effects of quercetin supplementation on body composition, exercise performance and muscle damage indices in athletes
Gholamreza Askari et al. · International journal of preventive medicine · 2013
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Does quercetin and vitamin C improve exercise performance, muscle damage, and body composition in male athletes?
Gholamreza Askari et al. · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012
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Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials
Daniel Rojano-Ortega et al. · Biology of sport · 2023
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Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
Denis M Pelletier et al. · International journal of sport nutrition and exercise metabolism · 2013

Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology