Tier 2 — strong

Effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep in ROTC cadets

Kevin A Bigelman, Donald P Chapman, Eric C Freese, Jennifer L Trilk, Kirk J Cureton
Military medicine 2011 176(5):565

Bibliography

PubMed
PMID 21634303
DOI
10.7205/milmed-d-09-00230
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled military-training trial
ModelHuman intervention research
Sample58 moderately trained young adults
InterventionQuercetin 1,000 mg/day in a soft chew or placebo
Duration42–54 days, with follow-up 2 weeks later
EndpointsCognitive, mood, or sleep measures

What the study showed, in plain terms

Published in 2011, this source examined brain, cognition and sleep. Design: Randomized double-blind placebo-controlled military-training trial. Sample/model: 58 moderately trained young adults. The exposure or intervention was Quercetin 1,000 mg/day in a soft chew or placebo. Follow-up or treatment period: 42–54 days, with follow-up 2 weeks later.

Energy, fatigue, and sleep quality did not improve relative to placebo.

Young military trainees and questionnaire outcomes limit generalization. This shares the trial program reported in the ROTC physical-performance paper.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Brain Fog, Memory and Sleep: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Energy, fatigue, and sleep quality did not improve relative to placebo.
  • The recorded outcome domains were Cognitive, mood, or sleep measures.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day in a soft chew or placebo; 42–54 days, with follow-up 2 weeks later.

What this study can and cannot tell us

  • Young military trainees and questionnaire outcomes limit generalization. This shares the trial program reported in the ROTC physical-performance paper.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Companion or correction records are linked below. They should not be counted automatically as independent replications; see the individual source notes for the relationship.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Effects of six weeks of quercetin supplementation on physical performance in ROTC cadets
Kevin A Bigelman et al. · Military medicine · 2010
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The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial
Joshua J Broman-Fulks et al. · Therapeutic advances in psychopharmacology · 2012
Tier 2
Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood
Craig A Olson et al. · Journal of clinical psychopharmacology · 2010

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology