Tier 2 — strong

Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood

Craig A Olson, Jennifer A Thornton, Gina E Adam, Harris R Lieberman
Journal of clinical psychopharmacology 2010 30(5):573

Bibliography

PubMed
PMID 20814335
DOI
10.1097/JCP.0b013e3181ee0f79
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignDouble-blind placebo-controlled acute vigilance experiment
ModelHuman intervention research
Sample57 volunteers
InterventionQuercetin dihydrate 2,000 mg, caffeine 200 mg, or placebo
DurationSingle dose; testing 1 hour later
EndpointsCognitive, mood, or sleep measures

What the study showed, in plain terms

Published in 2010, this source examined brain, cognition and sleep. Design: Double-blind placebo-controlled acute vigilance experiment. Sample/model: 57 volunteers. The exposure or intervention was Quercetin dihydrate 2,000 mg, caffeine 200 mg, or placebo. Follow-up or treatment period: Single dose; testing 1 hour later.

Caffeine improved vigilance and selected mood ratings; quercetin did not significantly change the measured outcomes.

Single high-dose laboratory experiment. Receptor activity in vitro did not translate into a caffeine-like effect in this study.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Brain Fog, Memory and Sleep: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Caffeine improved vigilance and selected mood ratings; quercetin did not significantly change the measured outcomes.
  • The recorded outcome domains were Cognitive, mood, or sleep measures.
  • The result applies to the tested exposure: Quercetin dihydrate 2,000 mg, caffeine 200 mg, or placebo; Single dose; testing 1 hour later.

What this study can and cannot tell us

  • Single high-dose laboratory experiment. Receptor activity in vitro did not translate into a caffeine-like effect in this study.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial
Joshua J Broman-Fulks et al. · Therapeutic advances in psychopharmacology · 2012
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Effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep in ROTC cadets
Kevin A Bigelman et al. · Military medicine · 2011

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology