Tier 2 — strong

Influence of quercetin supplementation on disease risk factors in community-dwelling adults

Amy M Knab, R Andrew Shanely, Dru A Henson, Fuxia Jin, Serena A Heinz, Melanie D Austin, David C Nieman
Journal of the American Dietetic Association 2011 111(4):542

Bibliography

PubMed
PMID 21443986
DOI
10.1016/j.jada.2011.01.013
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized placebo-controlled community trial
ModelHuman intervention research
Sample1,002 adults
InterventionQuercetin 500 or 1,000 mg/day with corresponding vitamin C and niacin, or placebo
Duration12 weeks
EndpointsBlood pressure; Lipid measurements; Inflammatory measures; Exposure and pharmacokinetics

What the study showed, in plain terms

Published in 2011, this source examined cardiovascular and metabolic health. Design: Randomized placebo-controlled community trial. Sample/model: 1,002 adults. The exposure or intervention was Quercetin 500 or 1,000 mg/day with corresponding vitamin C and niacin, or placebo. Follow-up or treatment period: 12 weeks.

Plasma quercetin increased, but overall effects on inflammatory, lipid, blood-pressure, and other disease-risk markers were small or negligible.

Multi-ingredient products and surrogate outcomes limit attribution and clinical inference. Several publications analyze outcomes from this same community trial.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Weight Loss, Blood Sugar and Fatty Liver: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Plasma quercetin increased, but overall effects on inflammatory, lipid, blood-pressure, and other disease-risk markers were small or negligible.
  • The recorded outcome domains were Blood pressure; Lipid measurements; Inflammatory measures; Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Quercetin 500 or 1,000 mg/day with corresponding vitamin C and niacin, or placebo; 12 weeks.

What this study can and cannot tell us

  • Multi-ingredient products and surrogate outcomes limit attribution and clinical inference. Several publications analyze outcomes from this same community trial.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Companion or correction records are linked below. They should not be counted automatically as independent replications; see the individual source notes for the relationship.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
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The variable plasma quercetin response to 12-week quercetin supplementation in humans
F Jin et al. · European journal of clinical nutrition · 2010
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Quercetin with vitamin C and niacin does not affect body mass or composition
Amy M Knab et al. · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2011
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The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial
Joshua J Broman-Fulks et al. · Therapeutic advances in psychopharmacology · 2012
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A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects
Serena A Heinz et al. · The British journal of nutrition · 2010
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Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults
Lynn Cialdella-Kam et al. · The British journal of nutrition · 2013

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology