Tier 2 — strong

Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run

David C Nieman, Dru A Henson, J Mark Davis, Charles L Dumke, Sarah J Gross, D Paul Jenkins, E Angela Murphy, Martin D Carmichael, John C Quindry, Steven R McAnulty, Lisa S McAnulty, Alan C Utter, Eugene P Mayer
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007 27(12):1003

Bibliography

PubMed
PMID 18184041
DOI
10.1089/jir.2007.0050
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled ultramarathon trial
ModelHuman intervention research
Sample63 randomized runners; 39 finishers analyzed
InterventionQuercetin 1,000 mg/day or placebo
Duration3 weeks before a 160-km race
EndpointsInflammatory measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2007, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled ultramarathon trial. Sample/model: 63 randomized runners; 39 finishers analyzed. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 3 weeks before a 160-km race.

Quercetin did not attenuate muscle-damage markers, cytokine responses, cortisol, or leukocyte cytokine-expression changes.

Same Western States cohort as related oxidative-stress and perceived-exertion reports; those publications are not independent replications.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin did not attenuate muscle-damage markers, cytokine responses, cortisol, or leukocyte cytokine-expression changes.
  • The recorded outcome domains were Inflammatory measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 3 weeks before a 160-km race.

What this study can and cannot tell us

  • Same Western States cohort as related oxidative-stress and perceived-exertion reports; those publications are not independent replications.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Companion or correction records are linked below. They should not be counted automatically as independent replications; see the individual source notes for the relationship.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition
John C Quindry et al. · International journal of sport nutrition and exercise metabolism · 2008
Tier 2
Quercetin does not affect rating of perceived exertion in athletes during the Western States endurance run
Alan C Utter et al. · Research in sports medicine (Print) · 2009
Tier 2
Post-160-km race illness rates and decreases in granulocyte respiratory burst and salivary IgA output are not countered by quercetin ingestion
D Henson et al. · International journal of sports medicine · 2008
Tier 1
Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials
Daniel Rojano-Ortega et al. · Biology of sport · 2023
Tier 2
Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
Denis M Pelletier et al. · International journal of sport nutrition and exercise metabolism · 2013

Citation network

Articles citing this research paper

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology