Tier 2 — strong

Microbiological and Pharmacokinetic Aspects of a Water-Soluble Quercetin 3-O-rutinoside, EubioQuercetin: A Direct Comparison With Quercetin in In Vitro and Human Clinical Studies

Naoto Yamaguchi, Yui Sudaka, Takafumi Mitsui, Ryohei Nakaguro, Misa Saito, Hiroaki Kida, Mitsunori Ono
Journal of food science 2025 90(10):e70579

Bibliography

PubMed
PMID 41014182
DOI
10.1111/1750-3841.70579
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized open-label crossover pharmacokinetic study with laboratory experiments
ModelHuman intervention research
SampleHuman crossover cohort; size not stated in abstract
InterventionWater-soluble quercetin-3-O-rutinoside formulation versus conventional quercetin
DurationAcute pharmacokinetics and 4-week supplementation
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2025, this source examined forms, absorption and food sources. Design: Randomized open-label crossover pharmacokinetic study with laboratory experiments. Sample/model: Human crossover cohort; size not stated in abstract. The exposure or intervention was Water-soluble quercetin-3-O-rutinoside formulation versus conventional quercetin. Follow-up or treatment period: Acute pharmacokinetics and 4-week supplementation.

The formulation produced higher and more sustained metabolite exposure, with preliminary microbiota changes.

A related glycoside formulation with laboratory and clinical components. Greater exposure does not by itself demonstrate superior clinical benefit.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Forms: Dihydrate, Phytosome, Liposomal and Glycosides. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The formulation produced higher and more sustained metabolite exposure, with preliminary microbiota changes.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Water-soluble quercetin-3-O-rutinoside formulation versus conventional quercetin; Acute pharmacokinetics and 4-week supplementation.

What this study can and cannot tell us

  • A related glycoside formulation with laboratory and clinical components. Greater exposure does not by itself demonstrate superior clinical benefit.
  • A change in blood exposure or a metabolic marker is not a demonstrated improvement in symptoms, disease events or lifespan. The tested formulation and co-administered medicines matter.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology