Tier 4 — mechanistic

Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions

Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH
The journals of gerontology. Series A, Biological sciences and medical sciences 2023 78; 12; 2435-2448

Bibliography

PubMed
PMID 37068054
PubMed Central
PMC10692436
Funding
Indexed grant support includes NHLBI NIH HHS, NIA NIH HHS, NIH HHS. The complete funding declaration is not specified in the accessible abstract.
Competing interests
The authors disclosed a ChromaDex material-transfer agreement and reported no commercial or financial relationships considered conflicts.

Study snapshot

DesignNarrative evidence review
ModelPublished clinical research literature
SampleHuman studies of NR, NR/pterostilbene and NMN
InterventionReview of chronic oral NAD+-precursor supplementation
DurationStudies available through the review’s search period
EndpointsEvidence synthesis and translational limitations

What the study showed, in plain terms

The review summarized tolerability, biochemical target engagement and varied physiological outcomes across human precursor studies.

Key findings

The review summarized tolerability, biochemical target engagement and varied physiological outcomes across human precursor studies.

What this study can and cannot tell us

Different compounds and populations are not interchangeable; short duration and small sample sizes limit many findings.

Editorial review

Reviewed by the Biohack Blueprint research team

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