Tier 1 — highest

Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis

Zhong O, Wang J, Tan Y, Lei X, Tang Z
Nutrition & metabolism 2022 19; 1; 20

Bibliography

PubMed
PMID 35303905
PubMed Central
PMC8932245
DOI
10.1186/s12986-022-00653-9
Funding
Funding/support listed in the publication: National Natural Science Fund of China; Natural Science Foundation of Hunan Province; Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City.
Competing interests
The authors reported no competing interests.

Study snapshot

DesignSystematic review and/or meta-analysis
ModelMeta-analysis of human clinical studies
Sample40 articles; 14750 participants across several precursor classes
InterventionNR, NMN, niacin and nicotinamide studies
DurationSearch through February 2021
EndpointsStudy-specific pooled or narratively synthesized outcomes

What the study showed, in plain terms

The meta-analysis found precursor-class differences, with lipid changes driven particularly by niacin; NR-specific lipid benefits were not established.

Key findings

The meta-analysis found precursor-class differences, with lipid changes driven particularly by niacin; NR-specific lipid benefits were not established.

What this study can and cannot tell us

Pooling multiple vitamin forms does not provide an NR-specific treatment estimate. The large overall denominator should not be presented as the number studied with NR.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology