Tier 4 — mechanistic

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+

Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C
Cell 2007 129; 3; 473-484

Bibliography

PubMed
PMID 17482543
DOI
10.1016/j.cell.2007.03.024
Funding
Indexed grant support includes NIGMS NIH HHS. The complete funding declaration is not specified in the accessible abstract.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignIn vitro or biochemical mechanistic study
ModelSaccharomyces cerevisiae
SampleYeast experiments
InterventionExogenous NR with genetic pathway manipulation
DurationReplicative lifespan and gene-silencing experiments
EndpointsNAD+ pathway or cellular-function measures

What the study showed, in plain terms

NR supported NAD+ synthesis, Sir2-related gene silencing and replicative lifespan in yeast through two salvage routes.

Key findings

NR supported NAD+ synthesis, Sir2-related gene silencing and replicative lifespan in yeast through two salvage routes.

What this study can and cannot tell us

Yeast replicative lifespan is not mammalian lifespan or a demonstrated human anti-aging effect.

Related papers in the corpus

Tier 3
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Liu L et al. · Cell metabolism · 2018
Tier 4
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Ratajczak J et al. · Nature communications · 2016
Tier 4
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
Bieganowski P et al. · Cell · 2004

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology