Tier 1 — highest

Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis

Ellen Ghm van den Heuvel, Paul Lips, Linda J Schoonmade, Susan A Lanham-New, Natasja M van Schoor
Advances in nutrition (Bethesda, Md.) 2024 15(1):100133

Bibliography

PubMed
PMID 37865222
PubMed Central
PMC10831883
DOI
10.1016/j.advnut.2023.09.016
Funding
The authors report no dedicated external funding for this publication.
Competing interests
The publication includes author disclosures; consult the linked source for the individual relationships and their relevance.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample20 comparative studies; 12 daily-dose comparisons in the LC-MS/MS analysis
InterventionDaily or once/twice-weekly D2 versus D3
DurationVaried across trials
EndpointsTotal and form-specific 25(OH)D; BMI-related response differences

What the study showed, in plain terms

This publication examines total and form-specific 25(oh)d, bmi-related response differences. Study population or evidence base: 20 comparative studies; 12 daily-dose comparisons in the LC-MS/MS analysis. Intervention or exposure: Daily or once/twice-weekly D2 versus D3.

Key findings

D3 generally raised total 25(OH)D more than D2, including in daily-dose studies. Body mass index influenced the observed difference.

What this study can and cannot tell us

Substantial heterogeneity and incomplete BMI data affect interpretation. The result concerns biochemical status rather than clinical outcomes.

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