Tier 1 — highest

Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial

Muhammad M Hammami, Ahmed Yusuf
BMC endocrine disorders 2017 17(1):12

Bibliography

PubMed
PMID 28231782
PubMed Central
PMC5324269
DOI
10.1186/s12902-017-0163-9
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from King Abdul-Aziz City for Science and Technology. See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample279 adults randomized; 269 contributed analyzable results
InterventionD2, D3, their combination or placebo with daily and intermittent schedules
Duration140 days
EndpointsVitamin D-metabolite exposure; Effects of schedule and sex

What the study showed, in plain terms

This publication examines vitamin d-metabolite exposure, effects of schedule and sex. Study population or evidence base: 279 adults randomized; 269 contributed analyzable results. Intervention or exposure: D2, D3, their combination or placebo with daily and intermittent schedules.

Key findings

Both forms raised vitamin D status, but responses depended on dosing schedule, baseline status and sex. D2 supplementation also lowered circulating 25(OH)D3 in some comparisons.

What this study can and cannot tell us

Multiple dosing arms and biochemical endpoints. The results do not define a universally superior schedule or a clinical-outcome difference.

Related papers in the corpus

Tier 1
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis
Laura Tripkovic et al. · The American journal of clinical nutrition · 2012
Tier 1
Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis
Rakesh Balachandar et al. · Nutrients · 2021
Tier 1
Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis
Ellen Ghm van den Heuvel et al. · Advances in nutrition (Bethesda, Md.) · 2024
Tier 1
Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
Michael F Holick et al. · The Journal of clinical endocrinology and metabolism · 2008

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research