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Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis

Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Nutrients 2021 13(10):3328

Bibliography

PubMed
PMID 34684328
PubMed Central
PMC8538717
DOI
10.3390/nu13103328
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample24 studies involving 1,277 participants
InterventionVitamin D3 compared with D2
DurationVaried across controlled studies
EndpointsVitamin D metabolites; Parathyroid hormone

What the study showed, in plain terms

This publication examines vitamin d metabolites, parathyroid hormone. Study population or evidence base: 24 studies involving 1,277 participants. Intervention or exposure: Vitamin D3 compared with D2.

Key findings

D3 produced a greater average increase in total 25(OH)D and more favorable PTH responses than D2 in the pooled analysis.

What this study can and cannot tell us

Included regimens and study designs differed. Greater improvement in blood vitamin D does not demonstrate fewer fractures or other clinical events.

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