Tier 3 — preclinical

Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

Yu J, Wang Y, Wang N, Zhang Y, Yu Q, Li J, Zhang R, Wang F, Zhang Q, Zhang J, Zhu J, Xu W, Peng B, Qu B, Liu L, Feng R
Free radical biology & medicine 2026 246:697-710

Bibliography

PubMed
PMID 41611034
DOI
10.1016/j.freeradbiomed.2026.01.050
Funding
Indexed support: Ministry of Industry and Information Technology of the People's Republic of China; National Natural Science Foundation of China; Natural Science Foundation of Heilongjiang Province; Key Research and Development Program of Heilongjiang. See the publication for grant and funder details.
Competing interests
The accessible abstract does not establish the authors' competing interests; absence of a statement is not evidence of no conflicts.

Study snapshot

DesignControlled animal intervention with mechanistic experiments
ModelFruit flies and aged rats
SampleMultiple fruit-fly and aged-rat experiments; n varies by assay
InterventionGlycine supplementation with Nmdmc pathway perturbation in flies and aging measures in rats
DurationModel-specific aging experiments
EndpointsFly lifespan; Stress resistance; Mitochondrial one-carbon metabolism; Rat tissue aging phenotypes

What the study showed, in plain terms

This 2026 study links glycine to mitochondrial one-carbon metabolism in flies and aged rats. Fly lifespan and selected rat tissue changes supply experimental rationale, not evidence of human rejuvenation.

Key findings

  • Nmdmc knockdown abolished key glycine-associated benefits in flies.
  • Aged rats showed selected histological and mitochondrial changes.

What this study can and cannot tell us

Different species and outcomes were used for different parts of the hypothesis.

No human intervention or human lifespan endpoint was tested.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction