Tier 3 — preclinical
Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
BMC genetics
2015
16:8
Bibliography
- PubMed
- PMID 25643626
- PubMed Central
- PMC4328591
- Funding
- Indexed support: NIA NIH HHS; NIH HHS. See the publication for grant and funder details.
- Competing interests
- No dedicated competing-interest declaration was identified in the retrieved full text; absence of a statement is not evidence of no conflicts.
Study snapshot
| Design | Controlled animal intervention with mechanistic experiments |
|---|---|
| Model | C. elegans; amino-acid screening and longevity mutants |
| Sample | Multiple C. elegans strains and amino-acid dose experiments |
| Intervention | Individual amino acids at three concentrations, with genetic and metabolic perturbations |
| Duration | Worm lifespan experiments |
| Endpoints | Lifespan; Stress responses; Nutrient-sensing pathways |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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