Tier 3 — preclinical
Glycine supplementation extends lifespan of male and female mice
Aging cell
2019
18(3):e12953
Bibliography
- PubMed
- PMID 30916479
- PubMed Central
- PMC6516426
- Funding
- US National Institute on Aging and Department of Veterans Affairs support, as detailed in the publication.
- Competing interests
- Joel Brind reported a commercial interest in Natural Food Science LLC, which sells a glycine supplement.
Study snapshot
| Design | Controlled animal intervention with mechanistic experiments |
|---|---|
| Model | Male and female UM-HET3 mice across three ITP sites |
| Sample | 292 glycine-treated mice and 580 controls in pooled survival counts; separate mechanistic/pathology subsets |
| Intervention | Diet containing nominally 8% glycine by weight from 9 months of age |
| Duration | Remaining lifespan at three ITP sites |
| Endpoints | Median and late-life survival; End-of-life pathology; Glycine exposure |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Editorial review
Reviewed by the Biohack Blueprint research team
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