Tier 2 — strong
Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research
Frontiers in pharmacology
2025
16:1460643
Bibliography
- PubMed
- PMID 40949129
- PubMed Central
- PMC12433188
- Funding
- Supported by the National Natural Science Foundation of China and Sichuan science/technology programs.
- Competing interests
- The publication contains author disclosures. Commercial relationships, employment, funding or other interests should be interpreted from the complete declaration; it is not classified here as conflict-free.
Study snapshot
| Design | Systematic review and meta-analysis |
|---|---|
| Model | Four clinical studies and 18 preclinical studies; separate human and animal findings |
| Sample | 22 studies: 4 clinical and 18 preclinical |
| Intervention | Evidence synthesis; interventions and comparators vary across included studies |
| Duration | No new treatment; included-study durations vary |
| Endpoints | Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting |
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